个人简介
周列民，男，中山大学附属第七医院副院长，神经内科主任医师，教授，医学博士，博士生导师。2001-2002年在澳大利亚贝克医学研究所作访问学者。主要从事难治性癫痫发病机制的基础和临床研究及抗癫痫药物基因组学的临床和基础研究。现任中华医学会神经科分会癫痫学组委员、中国抗癫痫协会常务理事、中国抗癫痫协会病友工作委员会副主任委员、中国医师协会神经科分会癫痫专业委员会委员、全国卫生产业企业管理协会健康服务适宜技术分会专家委员会特邀专家、广东省抗癫痫协会会长、癫痫杂志副主编。
专业擅长
主要从事难治性癫痫发病机制的基础和临床研究、抗癫痫药物基因组学的临床和基础研究。目前担任国际抗癫痫联盟（ILAE）会员、中国抗癫痫联盟常务理事、中国抗癫痫协会癫痫病友委员会副主任委员、广东省抗癫痫协会会长、中华神经科学会癫痫脑电图专业委员会委员、中国医师协会神经科分会癫痫脑电图专业委员会委员、CAAE精准医学与药物不良反应监测专业委员会副主委；《癫痫杂志》副主编、《中国临床神经科学》杂志编委会委员、《Epilepsia 杂志中文版》编委会委员、《神经电生理与癫痫杂志》编委会委员；《Brain Research》、 《Synapse》、 《 Lat. Am. J. Pharm 》等杂志审稿人。
科技成果
主持国家自然基金面上项目 3 项（近5年2项）、卫生部1项、教育部2项、省自然基金1项、 省科技厅基础条件建设项目2项。省卫生厅项目2项。共发表科研论文90余篇，其中 SCI 论文 20 余篇。共发表科研论文90余篇，其中 SCI 论文 20 余篇。参编专著14本、副主编专著2本。
论文：
1. Yishu Chen, Xiaokuo He, Qianqian Sun, Ziyan Fang, Liemin Zhou. Effect of lamotrigine on seizure development in a rat pentylenetetrazole kindling model. Brain and Behavior. 2017;e00727; 1-10.
2. Ni G, Qin J, Chen Z, Li H, Zhou J, Huang M, Zhou L. Associations between genetic variation in one-carbon metabolism and leukocyte DNA methylation in valproate-treated patients with epilepsy. Clin Nutr. 2017 Jan 20. pii: S0261-5614(17) 30004-3. doi: 10.1016/j.clnu.2017.01.004.
3. Hong Z, Inoue Y, Liao W, Meng H, Wang X, Wang W, Zhou L, Zhang L, Du X, Tennigkeit F; EP0008 Study Group.Efficacy and safety of adjunctive lacosamide for the treatment of partial-onset seizures in Chinese and Japanese adults: A randomized, double-blind, placebo-controlled study. Epilepsy Res. 2016 Nov;127:267-275. doi: 10.1016/j.eplepsyres.2016.08.032.
4. Cai X, Long L, Yang L, Chen Z, Ni G, Qin J, Zhou J, Zhou L.Association between mossy fiber sprouting and expression of semaphorin-3f protein in dentate gyrus of hippocampus in lithium-pilocarpine-induced status epilepticus mouse model. Neurol Res. 2016 Oct 17:1-6. [Epub ahead of print]
5. Fang Z, Chen S, Qin J, Chen B, Ni G, Chen Z, Zhou J, Li Z, Ning Y, Wu C, Zhou L. Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy. Biomaterials. 2016 Aug;97:110-21. doi: .1016/j.biomaterials.2016.04.021.
6. Zhou Y, Wang X, Li H, Zhang J, Chen Z, Xie W, Zhang J, Li J, Zhou L, Huang M.Polymorphisms of ABCG2, ABCB1 and HNF4α are associated with Lamotrigine trough concentrations in epilepsy patients. Drug Metab Pharmacokinet. 2015 Aug;30(4):282-7. doi: 10.1016/j.dmpk.2015.05.002.
7. Ni G, Qin J, Li H, Chen Z, Zhou Y, Fang Z, Chen Y, Zhou J, Huang M, Zhou L.Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy. PLoS One. 2015 Apr 27;10(4):e0125656. doi: 10.1371/journal.pone.0125656.
8. Li H, Wang X, Zhou Y, Ni G, Su Q, Chen Z, Chen Z, Li J, Chen X, Hou X, Xie W, Xin S, Zhou L, Huang M.Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid. Int J Neuropsychopharmacol. 2015 Mar 3;18(7):pyv021. doi: 10.1093/ijnp/pyv021.
9. Ni G, Qin J, Fang Z, Chen Y, Chen Z, Zhou J, Zhou L.Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis. BMJ Open. 2014 Jul 16;4(7):e004936. doi: 10.1136/bmjopen-2014-004936. Review.
10. Ziyan FANG, Shuda CHEN, Yishu CHEN , Guanzhong NI , Jiaming QIN1, Libai YANG ,Ziyi CHEN, Jueqian ZHOU, Min HUANG, Chuanbin WU, Ze LI, Liemin ZHOU *.Pluronic P85 Enhances the Delivery of Phenytoin to the Brain Versus Verapamil In Vivo. Latin American Journal of Pharmacy - 33 (5) – 2014.
11. Yang L, Cai X, Zhou J, Chen S, Chen Y, Chen Z, Wang Q, Fang Z, Zhou L. STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy. PLoS One. 2013 Sep 13;8(9):e74614. doi: 10.1371/journal.pone.0074614.
12. Cai X, Yang L, Zhou J, Zhu D, Guo Q, Chen Z, Chen S, Zhou L.Anomalous expression of chloride transporters in the sclerosed hippocampus of mesial temporal lobe epilepsy patients. Neural Regen Res. 2013 Feb 25;8(6):561-8. doi: 10.3969/j.issn.1673-5374.2013.06.010.
13. Zhou JQ, Zhou LM, Chen LJ, Han JD, Wang Q, Fang ZY, Chen ZY, Ling S.Polycystic ovary syndrome in patients with epilepsy: a study in 102 Chinese women. Seizure. 2012 Nov;21(9):729-33. doi: 10.1016/j.seizure.2012.08.001
14. Zhou JQ, Zhou LM, Fang ZY, Wang Q, Chen ZY, Yang LB, Chen SD, Cai XD.Analyzing clinical and electrophysiological characteristics of Paroxysmal Dyskinesia. J Res Med Sci. 2011 Jan;16(1):110-4.
15. Wang Q, Zhou JQ, Zhou LM, Chen ZY, Fang ZY, Chen SD, Yang LB, Cai
XD, Dai QL, Hong H, Wang HX.Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland.Seizure. 2011 Jul;20(6):446-8.
16. Chen Z, Chen S, Chen L, Zhou J, Dai Q, Yang L, Li X, Zhou L .Long-term increasing co-localization of SCN8A and ankyrin-G in rat hippocampal cornu ammonis 1 after pilocarpine induced status epilepticus. Brain Res. 2009 May 13;1270:112-20. doi: 10.1016/j.brainres.2009.03.012.
17. Li X, Zhou J, Chen Z, Chen S, Zhu F, Zhou L. Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE). Brain Res. 2008 Jul 24;1221:141-6. doi: 10.1016/j.brainres.2008.04.047.
18. Ling S, Zhou L, Li H, Dai A, Liu JP, Komesaroff PA, Sudhir K. Effects of 17beta-estradiol on growth and apoptosis in human vascular endothelial cells: influence of mechanical strain and tumor necrosis factor-alpha. Steroids. 2006 Sep;71(9):799-808.
19. Liemin Zhou, et al.Hippocampal pathology and inhibitory neurotransmitter GABA immunoreactivity in patties with medically intractable temporal lobe epilepsy. Epilepsia 2005; 46(suppl 6):547.
20. Chen ZY, Zhou LM*. Investigation of cognitive function in epilepsy and exploration of the independent risk factors. Epilepsia 2005; 46(suppl 6): 991.
21. Jueqian Zhou, Liemin Zhou*, et al. Clinical study of paroxysmal kinesigenic horeoathetosis. Epilepsia 2005; 46(suppl 6):282.
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