原 著：《The Osteoporosis Manual》译 著：《骨质疏松手册》

This comprehensive manual covers all aspects of the prevention, diagnosis and management of osteoporosis, offering an upbeat and optimistic assessment of what can be achieved. While scientifically based, the book provides easy-to-follow guidelines for lifelong maintenance of skeletal structure and function. It deals with everything from the basic physiology of bone and mineral metabolism to the diagnostic utility of radiologic imaging and specialized tests and current treatment recommendations, including for fracture management. The relationship of osteoporosis to a variety of other disorders is also thoroughly explored and elucidated. 

Osteoporosis represents a global threat because every human being is vulnerable to it as time passes. The authors point out the enormous scale of the problem in terms of the human suffering, morbidity, and mortality on the one hand and the associated astronomical national and global costs on the other. Osteoporosis is preventable, and every doctor in every medical discipline can contribute to this goal. And though prevention is better than cure, it is never too late for effective therapy, as outlined in this book.

Bone is every doctorʼs and every bodyʼs business!

1. Evolution of the Skeleton

2. Structure and Architecture of Bone 

3. Modelling and Remodelling of Bone 

4. Control and Regulation of Bone Remodelling 

5. Growth and Ageing of Bone 

6. Clinical Evaluation 

7. Skeletal Radiology 

8. Bone Densitometry 

9. Laboratory Investigations 

10. Bone and Bone Marrow Biopsy 

11. Epidemiology of Osteoporosis 

12. Definition of Osteoporosis 

13. Pathogenesis of Osteoporosis 

14. Subgroups of Osteoporosis 

15. Clinical Evaluation of Osteoporosis 

16. Risk Factors for Osteoporosis and Fractures 

17. A Step-by-Step Programme for Healthy Bones

18. Physical Activity and Exercise Programmes 

19. Calcium and Other Minerals 

20. Vitamin D and Other Useful Vitamins 

21. Hormone Replacement Therapy (HRT) 

22. Management of Pain in Osteoporosis 

23. Treatment Strategies in Osteoporosis 

24. Bisphosphonates (BPs)

25. Other Drugs in Osteoporosis 

26. Adherence and Monitoring of Osteoporosis Therapy 

27. Future Directions 

28. Epidemiology of Osteoporotic Fractures 

29. Risk Factors of Osteoporotic Fractures 

30. Fracture Healing 

31. Management of Osteoporotic Fractures 

32. Fractures in Rare Bone Disorders 

33. Falls and Fall Prevention 

34. Osteoporosis in Men 

35. Osteoporosis in Children and Adolescents 

36. Premenopausal Osteoporosis 

37. Pregnancy-Associated Osteoporosis 

38. Immobilisation Osteoporosis (Disuse Osteoporosis, Disuse Atrophy) 

39. Assessment of Secondary Osteoporosis

40. Cardiology 

41. Endocrinology 

42. Gastroenterology 

43. Genetics 

44. Haematology and Storage Disorders 

45. Infectious Disorders 

46. Nephrology 

47. Neurology and Psychiatry 

48. Oncology 

49. Pulmonology 

50. Rheumatology and Immunology 

51. The Patient with “Hypocalcaemia” 

52. Osteomalacia and Rickets 

53. AIDS Osteopathy 

54. The Patient with “Hypercalcaemia” 

55. Primary Hyperparathyroidism (pHPT) 

56. Paget’s Disease of the Bone 

57. Fibrous Dysplasia 

58. Vanishing Bone Disease (Gorham-Stout Syndrome) 

59. SAPHO Syndrome 

60. Bone Marrow Oedema Syndrome

61. Complex Regional Pain Syndrome (CRPS, Sudeck’s Disease)

62. Ischaemic Bone Disease

63. Oral Bone Loss Due to Periodontitis and Systemic Osteoporosis

64. Corticosteroid-Induced Osteoporosis

65. Transplantation Osteoporosis

66. Tumour Therapy-Induced Osteoporosis

67. Drug-Induced Osteoporomalacia

68. Antiepileptic Drug-Related Osteopathy

69. Other Drugs Associated with Osteoporosis

70. The “Bone and Marrow” System

71. The Patient with “Myelogenous Osteopathy”

72. Anaemias and Bone Reactions

73. Leukaemias and Lymphomas of the Bone

74. Myelofibrosis/Osteomyelosclerosis Syndrome (MF/OMS)

75. Disorders of the Mononuclear Phagocyte System

76. Systemic Mastocytosis (SM)

77. Multiple Myeloma

78. Tumour-Induced Hypercalcaemia (TIH)

79. Tumour-Induced Bone Pain (TIBP)

80. Bone Metastases: Incidence and Development

81. Skeletal Metastases of Breast and Prostate Cancer

82. Other Tumours with Osteotropic Metastases

83. The Normal Joint

84. Pathogenesis of Bone Reactions in Joint Disorders

85. Subchondral Cysts

86. Bone Reactions in Rheumatic Disorders

87. Degenerative, Metabolic and Neurogenic Joint Diseases

88. Peri-Implant Bone Loss

89. Renal Osteodystrophy (ROD)

90. Haemodialysis-Associated Amyloidosis

91. Kidney Stones

92. Bone and Muscles

93. Bone and Skin

94. Bone and Fatty Tissue

95. Bone and Central Nervous System

96. Bone and Immune System

97. Bone and Teeth